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In case you are looking for colocation, IP transit or other related services, check out our free quote service. If you would like a more user friendly listing of the locations, please visit our map, directory or search function. Targeting self-renewal aggressive stem-cell like cancer cell proliferation, with higher water solubility and lower cytotoxicity, musarin has shown strong potence to be developed as a promising novel therapeutic drug candidate against colorectal cancers, especially those that acquire chemo-resistance.This functions as a sitemap / index for the world wide colocation directory list, Data Center Map, showing all colocation housing facilities sorted by location. In addition, oral ingestion of musarin significantly inhibited CD24 +CD44 + HT29 generated tumor development in SCID/NOD mice with less side effects in microgram doses. Musarin strongly attenuated EGFR expression and down-regulated phosphorylation level, thereby slowing cancer cells proliferation. Musarin demonstrated tyrosine kinase inhibitory activity in vitro. Through whole transcription profile and gene enrichment analysis of musarin-treated CSCs-like cells, major signaling pathways and network modulated by musarin have been enriched, including the bioprocess of the Epithelial-Mesenchymal Transition, the EGFR-Ras signaling pathway and enzyme inhibitor activity.
Furthermore, Musarin, in particular, strongly inhibits aggressive human colorectal cancer stem cell-like CD24 +CD44 + HT29 proliferation in vitro and in a NOD/SCID murine xenograft model. The protein sequence of musarin was determined through enzyme digestion and MS/MS analysis.
In this study, we characterized a novel 12-kDa protein that named musarin, which was purified from Trametes versicolor mushroom extract and showed significant growth inhibition on multiple human colorectal cancer cell lines in vitro. Trametes versicolor mushroom extract demonstrates strongly cell growth inhibitory activity on human colorectal tumor cells.
Trametes versicolor is a traditional Chinese medicinal mushroom with a long history of being used to regulate immunity and prevent cancer. Colorectal cancer is the second deadly cancer in the world.
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